STUDIES ON HYPERSENSITIVITY
نویسندگان
چکیده
منابع مشابه
Studies on Hypersensitivity
In earlier observations with the picryl system, it was concluded that contact sensitivity was a form of delayed (cellular) hypersensitivity to conjugates of sensitizer with autologous proteins indistinguishable in its immunological mechanism from other classical forms of delayed hypersensitivity to proteins. This conclusion has been confirmed and extended with the picryl and chlorbenzoyl chlori...
متن کاملStudies on Delayed Hypersensitivity
Experiments carried out with several well defined antigenic systems (hapten conjugates of poly-L-lysine and guinea pig serum albumin) in guinea pigs demonstrated that: 1. Arthus reactions also manifest carrier specificity, although to a smaller extent than do delayed hypersensitivity reactions. 2. Desensitization by injection of minute doses of antigen results in moderate specific desensitizati...
متن کاملStudies on the Mechanisms of Hypersensitivity Phenomena
Human leukocytes, isolated from the blood of ragweed-sensitive donors, release histamine upon reaction with a purified protein antigen derived from this pollen. The release process has been studied with washed cells suspended in a defined, serum-free medium. Physiologic levels of pH, ionic strength, and temperature, as well as both calcium and magnesium, are required for optimal cellular reacti...
متن کاملStudies on the Mechanism of Hypersensitivity Phenomena
Experiments are described indicating that the magnitude and sensitivity of the passive cutaneous anaphylaxis (PCA) response in normal rats to a given level of immune reagents, may be enhanced by the addition of hemolytically active sera. A similar enhancement in normal rats has been obtained with C' component reagents possessing properties associated with the third component of C'. Parallelisms...
متن کاملEarly Physiological Studies on Elicitation of Hypersensitivity
It has now been nearly 40 years since the first observations by Klement (Klement, 1963) that resistance to bacterial plant pathogens was correlated with a rapid necrotic response induced in artificially inoculated tissue. This response, subsequently termed the hypersensitive response (HR) (Klement et al., 1964), was initially defined as a rapid necrosis observed within 24 h after inoculation of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1961
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.113.3.571